Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques

authored by

A. N. Generalova, B. N. Chichkov, E. V. Khaydukov

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

External Organisation(s)

Russian Academy of Sciences (RAS)
Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
Laser Zentrum Hannover e.V. (LZH)
Sechenov First Moscow State Medical University

Type

Review article

Journal

Advances in Colloid and Interface Science

Volume

245

Pages

1-19

No. of pages

19

ISSN

0001-8686

Publication date

04.05.2017

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Surfaces and Interfaces, Physical and Theoretical Chemistry, Colloid and Surface Chemistry

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1016/j.cis.2017.05.006 (Access: Closed)