Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques

verfasst von

A. N. Generalova, B. N. Chichkov, E. V. Khaydukov

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

Externe Organisation(en)

Russian Academy of Sciences (RAS)
Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences
Laser Zentrum Hannover e.V. (LZH)
Sechenov First Moscow State Medical University

Typ

Übersichtsarbeit

Journal

Advances in Colloid and Interface Science

Band

245

Seiten

1-19

Anzahl der Seiten

19

ISSN

0001-8686

Publikationsdatum

04.05.2017

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Oberflächen und Grenzflächen, Physikalische und Theoretische Chemie, Kolloid- und Oberflächenchemie

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1016/j.cis.2017.05.006 (Zugang: Geschlossen)