3D models of the bone marrow in health and disease

yesterday, today, and tomorrow

authored by

Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck

Abstract

The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.

External Organisation(s)

Karlsruhe Institute of Technology (KIT)

Type

Article

Journal

MRS communications

Volume

9

Pages

37-52

No. of pages

16

ISSN

2159-6859

Publication date

15.03.2019

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

General Materials Science

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://europepmc.org/articles/pmc6436722 (Access: Open)
https://doi.org/10.1557/mrc.2018.203 (Access: Closed)