3D models of the bone marrow in health and disease

yesterday, today, and tomorrow

verfasst von

Annamarija Raic, Toufik Naolou, Anna Mohra, Chandralekha Chatterjee, Cornelia Lee-Thedieck

Abstract

The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.

Externe Organisation(en)

Karlsruher Institut für Technologie (KIT)

Typ

Artikel

Journal

MRS communications

Band

9

Seiten

37-52

Anzahl der Seiten

16

ISSN

2159-6859

Publikationsdatum

15.03.2019

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Allgemeine Materialwissenschaften

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://europepmc.org/articles/pmc6436722 (Zugang: Offen)
https://doi.org/10.1557/mrc.2018.203 (Zugang: Geschlossen)