Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives

authored by
Torsten Busch, Gerald Dräger, Eike Kunst, Hannah Benson, Florenz Sasse, Karsten Siems, Andreas Kirschning
Abstract

The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines.

Organisation(s)
Institute of Organic Chemistry
Centre of Biomolecular Drug Research (BMWZ)
External Organisation(s)
Helmholtz Centre for Infection Research (HZI)
AnalytiCon Discovery GmbH, Potsdam
Type
Article
Journal
Organic and Biomolecular Chemistry
Volume
14
Pages
9040-9045
No. of pages
6
ISSN
1477-0520
Publication date
2016
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Biochemistry, Physical and Theoretical Chemistry, Organic Chemistry
Sustainable Development Goals
SDG 3 - Good Health and Well-being
Electronic version(s)
https://doi.org/10.1039/c6ob01697a (Access: Unknown)