In silico comparison of control strategies of insulin therapy for type 1 diabetes during physical activity using the extended sorensen glucoregulatory model

authored by

B. Romanski, C. Benner, Birgit Glasmacher, S. Leonhardt, Marian Walter

Abstract

Blood glucose level in patients with diabetes mellitus type 1 is controlled by external administration of insulin. Physical activity is a disturbance in blood glucose control, as it influences the glucoregulatory system significantly. In this paper, strategies for improving blood glucose control during physical activity are examined and compared using an extended version of the Sorensen glucoregulatory model. Investigated control strategies for open loop control are a feedforward compensator, which is informed about the intensity of performed activity, and an adaption of insulin infusion rate according to a fixed pattern. Control strategies for closed loop control are a PID controller, a combination of a PID controller and a feedforward compensator and a PID controller, whose setpoint is increased during activity. Results show that best blood glucose control is achieved with strategies including the feedforward compensator due to the achieved reduction of the deviation from the basal value, reduction of time in hypoglycemia and increase in minimal blood glucose level.

Organisation(s)

Institute of Multiphase Processes

External Organisation(s)

RWTH Aachen University

Type

Conference contribution

No. of pages

4

Publication date

09.08.2019

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

General Physics and Astronomy

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1063/1.5121982 (Access: Closed)