Trend tests for dichotomous endpoints with application to carcinogenicity studies

authored by

Markus Neuhäuser, Ludwig A. Hothorn

Abstract

A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend.

Organisation(s)

Department of Biostatistics

External Organisation(s)

SOLVAY GmbH

Type

Article

Journal

Therapeutic Innovation & Regulatory Science

Volume

31

Pages

463-469

No. of pages

7

ISSN

2168-4790

Publication date

30.12.1997

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Public Health, Environmental and Occupational Health, Pharmacology (medical)

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1177/009286159703100217 (Access: Closed)
https://doi.org/10.15488/3057 (Access: Open)