In Vivo Imaging of Drug Action

authored by

Oliver Plettenburg, Matthias Löhn

Abstract

In vivo imaging has evolved to be one of the most powerful methods to assist modern drug development, and to enable monitoring of disease progression in longitudinal studies by noninvasive methods in living animals. This chapter discusses the general principles and concepts of in vivo imaging and probe design, that are used to visualize the distribution behavior and effects of drug treatment. It provides some selected case studies in the areas of oncology, CNS, and diabetes. Some examples for translating these results into clinical practice are also discussed. The imaging techniques discussed in the chapter are magnetic resonance imaging (MRI), X-ray computer tomography (CT), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence-or luminescence-based technologies. Key to success is an early, reliable diagnosis, and allowing clear assessment of the actual disease stage, thus opening up opportunities for therapeutic intervention at an early point in time.

External Organisation(s)

Sanofi-Aventis Deutschland GmbH

Type

Contribution to book/anthology

Pages

465-501

No. of pages

37

Publication date

26.09.2015

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

General Chemistry, General Chemical Engineering, General Biochemistry,Genetics and Molecular Biology

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1002/9781118771723.ch16 (Access: Closed)