Modifications of the closure principle for analyzing toxicological studies

authored by

Ludwig A. Hothorn

Abstract

A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held on March, 25-27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper proposes a simple closure test for dose-response relationships under real data conditions. This approach takes into account deviation from variance homogeneity and monotonicity assumptions. Moreover, this approach can be easily adapted for “any” kind of two-sample tests, for example, nonparametric, dichotomous, censored, and so forth. Power was compared by a simulation study for selected conditions.

Organisation(s)

Department of Biostatistics

Type

Article

Journal

Therapeutic Innovation & Regulatory Science

Volume

31

Pages

403-412

No. of pages

10

ISSN

2168-4790

Publication date

30.12.1997

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Public Health, Environmental and Occupational Health, Pharmacology (medical)

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Electronic version(s)

https://doi.org/10.1177/009286159703100211 (Access: Closed)
https://doi.org/10.15488/3022 (Access: Open)