An Introduction to MPEG-G

The First Open ISO/IEC Standard for the Compression and Exchange of Genomic Sequencing Data.

verfasst von

Jan Voges, Mikel Hernaez, Marco Mattavelli, Jörn Ostermann

Abstract

The development and progress of high-throughput sequencing technologies have transformed the sequencing of DNA from a scientific research challenge to practice. With the release of the latest generation of sequencing machines, the cost of sequencing a whole human genome has dropped to less than 600. Such achievements open the door to personalized medicine, where it is expected that genomic information of patients will be analyzed as a standard practice. However, the associated costs, related to storing, transmitting, and processing the large volumes of data, are already comparable to the costs of sequencing. To support the design of new and interoperable solutions for the representation, compression, and management of genomic sequencing data, the Moving Picture Experts Group (MPEG) jointly with working group 5 of ISO/TC276 'Biotechnology' has started to produce the ISO/IEC 23092 series, known as MPEG-G. MPEG-G does not only offer higher levels of compression compared with the state of the art but it also provides new functionalities, such as built-in support for random access in the compressed domain, support for data protection mechanisms, flexible storage, and streaming capabilities. MPEG-G only specifies the decoding syntax of compressed bitstreams, as well as a file format and a transport format. This allows for the development of new encoding solutions with higher degrees of optimization while maintaining compatibility with any existing MPEG-G decoder.

Organisationseinheit(en)

Institut für Informationsverarbeitung

Externe Organisation(en)

University of Illinois Urbana-Champaign (UIUC)
University of Navarra
Eidgenössische Technische Hochschule Lausanne (ETHL)

Typ

Artikel

Journal

Proc. IEEE

Band

109

Seiten

1607-1622

Anzahl der Seiten

16

Publikationsdatum

09.2021

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Elektrotechnik und Elektronik, Allgemeine Computerwissenschaft

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://doi.org/10.1109/JPROC.2021.3082027 (Zugang: Offen)