Antimicrobial photodynamic inactivation as a means to improve the safety of temporary polymer implants

verfasst von: Alina Rahtz, Romina Berger, Alexander Schweigerdt, Marie Weinhart, Tammo Ripken, Sonja Johannsmeier
Abstract: Advances in medical care and an aging population have resulted in an increased routine use of temporary implants, such as catheters or venous shunts. While these devices can greatly improve the quality of life of the patients, they also pose a constant risk of infection. This is especially concerning for vulnerable groups such as cancer and elderly patients. Additionally, each infection that is treated with antibiotics increases the risk of resistance development. Hospitals in particular need to avoid nosocomial infections to prevent spreading of resistant strains and ensure the safety of their patients. There is hence a high demand for innovative solutions to prevent infections in such vulnerable settings. In this context, antimicrobial photodynamic inactivation can serve as an effective means of in situ disinfection for otherwise hard to treat components. In our study, we focus on its possible application on temporary polymer implants such as catheters or shunts. In situ disinfection of such implants requires a non-toxic method and remote application. This can potentially be realized using appropriate waveguides and stable photodynamic agents. The work presented here lays the foundation for such self-disinfecting implants.
Organisationseinheit(en): Institut für Physikalische Chemie und Elektrochemie
Externe Organisation(en): Laser Zentrum Hannover e.V. (LZH)
NIFE- Niedersächsisches Zentrum für Biomedizintechnik, Implantatforschung und Entwicklung
Freie Universität Berlin (FU Berlin)
Typ: Aufsatz in Konferenzband
Publikationsdatum: 19.03.2025
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Elektronische, optische und magnetische Materialien, Atom- und Molekularphysik sowie Optik, Biomaterialien, Radiologie, Nuklearmedizin und Bildgebung
Ziele für nachhaltige Entwicklung: SDG 3 – Gute Gesundheit und Wohlergehen
Elektronische Version(en): https://doi.org/10.1117/12.3041085 (Zugang: Geschlossen)