ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

verfasst von

Christian Von Loeffelholz, Andreas F.H. Pfeiffer, Johan F. Lock, Steffi Lieske, Stephanie Döcke, Veronica Murahovschi, Jennifer Kriebel, Tonia De Las Heras Gala, Harald Grallert, Natalia Rudovich, Martin Stockmann, Joachim Spranger, Gerhard Jahreis, Stefan R. Bornstein, George Lau, Aimin Xu, Jeanette Schulz-Menger, Louisa Exner, Sven Haufe, Jens Jordan, Stefan Engeli, Andreas L. Birkenfeld

Abstract

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

Externe Organisation(en)

Deutsches Institut für Ernährungsforschung
Friedrich-Schiller-Universität Jena
Charité - Universitätsmedizin Berlin
Deutsches Zentrum für Diabetesforschung e.V. (DZD)
Julius-Maximilians-Universität Würzburg
Universitätsklinikum Carl Gustav Carus Dresden
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
The University of Hong Kong
Medizinische Hochschule Hannover (MHH)
Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR)
Technische Universität Dresden
King's College London
Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft

Typ

Artikel

Journal

Hormone and metabolic research

Band

49

Seiten

343-349

Anzahl der Seiten

7

ISSN

0018-5043

Publikationsdatum

01.05.2017

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Endokrinologie, Diabetes und Stoffwechsel, Biochemie, Endokrinologie, Klinische Biochemie, Biochemie, medizinische

Ziele für nachhaltige Entwicklung

SDG 3 – Gute Gesundheit und Wohlergehen

Elektronische Version(en)

https://elib.dlr.de/118757/1/Pub_Jordan_2017_5.pdf (Zugang: Offen)
https://doi.org/10.1055/s-0043-102950 (Zugang: Geschlossen)