An overview on the mechanisms of encapsulation of polyphenols used to help fight diabetes mellitus

authored by: Stephen Adeniyi Adefegha, Patricia Oyeronke Ogundare, Ganiyu Oboh, Tuba Esatbeyoglu, Jutta Papenbrock
Abstract: Diabetes mellitus (DM) represents a condition of deadly physiological condition characterized by a rate that has increased significantly in the past couple of decades. As the condition's incidence and severity increase, many medicinal techniques are being explored as potential solutions. Among is dietary polyphenols that was documented for their efficacy in addressing diabetes and related conditions such as cardio-respiratory implications, for various treatment endpoints. However, these biological properties of polyphenol are faced with challenges; this includes their instantaneous removal, a lack of water solubility, volatility at a low pH value, and sized particles which can affect its bioavailability and effectiveness. In order to overcome this challenge, nanotechnology (nanoencapsulation) which represents a fascinating niche for investigative work is then applied in order to further improve the diagnostic and therapeutic value of this compound (polyphenol). This current article aims to discuss the several research results that have been done and reported on the nanoencapsulation polyphenols' approach in the onset of type 2 diabetes.
Organisation(s): Institute of Food Science and Human Nutrition
Institute of Food and One Health
Molecular Food Chemistry and Food Development
Institute of Botany
External Organisation(s): Federal University of Technology, Akure
Type: Review article
Journal: Discover Food
Volume: 5
No. of pages: 26
ISSN: 2731-4286
Publication date: 09.06.2025
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Agricultural and Biological Sciences (miscellaneous), Agronomy and Crop Science, Aquatic Science, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Electronic version(s): https://doi.org/10.1007/s44187-025-00455-x (Access: Open)